Adenosine A2A receptor agonist (regadenoson) in human lung transplantation
نویسندگان
چکیده
منابع مشابه
Detection of coronary stenosis with myocardial contrast echocardiography using regadenoson, a selective adenosine A2A receptor agonist.
AIMS Regadenoson is comparable to adenosine in pharmacologic radionuclide stress tests but has not been studied with stress myocardial contrast echocardiography. This study assessed the haemodynamic profile and ability of regadenoson, a novel selective A(2A) receptor agonist, to detect coronary artery stenosis during myocardial contrast echocardiography. METHODS AND RESULTS Myocardial contras...
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Adenosine A2A receptor (A2AR) agonists reduce invariant natural killer T (iNKT) cell activation and decrease inflammation in sickle cell disease (SCD) mice. We conducted a phase 1 trial of the A2AR agonist regadenoson in adults with SCD. The target dose was 1.44 μg/kg/h. iNKT cell activation was evaluated using antibodies targeting the p65 subunit of nuclear factor-κB (phospho-NF-κB p65), inter...
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Agonists bind with higher affinity to G protein-coupled heptahelical receptors than to uncoupled receptors. Recombinant A1 and A3 adenosine receptors couple well to Gi/o, but recombinant human A2A adenosine receptors (hA2AAR) couple poorly to Gs and bind agonists with Ki values in binding assays that are much higher than ED50 values for functional responses such as coronary dilation and inhibit...
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ژورنال
عنوان ژورنال: The Journal of Heart and Lung Transplantation
سال: 2020
ISSN: 1053-2498
DOI: 10.1016/j.healun.2020.02.003